Regulation of TLR expression, a new perspective for the role of VIP in immunity

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• 作者：R.P. Gomariz ; A. Arranz ; Y. Juarranz ; I. Gutierrez-Cañ ; as ; M. Garcia-Gomez ; J. Leceta ; C. Martí ; nez
• 关键词：Neuroimmunomodulation ; Vasoactive intestinal peptide ; Toll-like receptors
• 刊名：Peptides
• 出版年：2007
• 出版时间：September 2007
• 年：2007
• 卷：28
• 期：9
• 页码：1825-1832
• 全文大小：372 K

文摘

The contribution of VIP immune functions to the regulation of homeostasis and health is well known. Modulation of immune responses through new therapeutics is one of the main goals of physicians and scientists seeking to control inflammatory/autoimmune diseases in humans. Initial therapeutic strategies targeted adaptive immune responses; discovery of Toll-like receptors (TLR) has widened the horizon to include targeting the innate immune system. In this review we have summarized recent information about VIP modulation of TLR function, and we suggest that VIP represents a new therapeutic option in the management of several pathologies.