Generation and characterization of monoclonal antibody against Advanced Glycation End Products in chronic kidney disease
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- 作者：Alessandra Becker Fincoa ; Ricardo Andrez Machado-de-Á ; vilab ; Rayana Macielc ; Juliana De Mouraa ; Philippe Billialdd ; Andrea Emilia Marques Stinghenc ; Larissa M. Alvarengaa ; lmalvarenga@ufpr.br" class="auth_mail" title="E-mail the corresponding author ; lmalvarenga@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Age ; CML ; Monoclonal antibody ; Chronic kidney disease
- 刊名：Biochemistry and Biophysics Reports
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：6
- 期：Complete
- 页码：142-148
- 全文大小：1118 K
文摘
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We isolated a monoclonal antibody able to recognize carboxymethyl lysine (CML) which is the major antigenic AGE compound.
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A sensitive immunoassay was developed to detect and quantify CML in biological samples.
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A correlation between chronic kidney disease (CKD) grade and the CML concentration deduced from the immunoassay was observed.