Identify the association between serum uric acid and adverse maternal and perinatal outcomes. More specifically, the correlation of maternal UA serum concentration with newborn size for gestational age and maternal proteinuria.
Cross observational study in pregnant women with pre-eclampsia, which were stratified according to dose of serum uric acid into two groups, as follow: I (below 6 mg/dL) and II (greater or equal to 6 mg/dL). Maternal and perinatal adverse outcomes were examined. Results were analyzed by T-Student and chi-square tests and correlations were evaluated by Pearson test. The level of significance used was 5%.
In group II there were a greater frequency of hypertensive crisis, eclampsia, partial HELPP syndrome and HELLP syndrome. Also it were observed an increased number of small newborns for gestational age, lower weight of the newborn, the higher percentage of fetal death, prematurity and index Apgar at 1 min.
The results suggest that patients with higher uric acid have worse adverse outcomes both for the mother and the newborn. In conclusion, the dosage of maternal serum uric acid associated with other clinical and laboratory tests can help in obstetrical practice.