Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives
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- 作者：Arthur E. Kü ; mmerle ; Juliana M. Raimundo ; Carla M. Leal ; Givanildo S. da Silva ; Tatiane L. Balliano ; Mariano A. Pereira ; Carlos A. de Simone ; Roberto T. Sudo ; Gisele Zapata-Sudo ; Carlos A.M. Fraga ; Eliezer J. Barreiro
- 关键词：N-Acylhydrazone ; Vasodilation ; Bioactive conformation
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2009
- 出版时间：October 2009
- 年：2009
- 卷：44
- 期：10
- 页码：4004-4009
- 全文大小：380 K
文摘
In this report we disclose the synthesis, vasodilatory activity, and identification of bioactive conformation of new N-acylhydrazone and N-methyl-N-acylhydrazone derivatives, structurally designed by bioisosteric replacements of previously described cardioactive compounds LASSBio-294 and its N-methyl derivative LASSBio-785. Some of these novel derivatives presented improved vasorelaxant properties, being new cardiovascular drug candidates.