The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer
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- 作者：É ; tienne Audet-Walsh1 ; 6 ; David J. Papadopoli1 ; 2 ; 6 ; Simon-Pierre Gravel1 ; Tracey Yee1 ; 2 ; Gaë ; lle Bridon1 ; Maxime Caron3 ; Guillaume Bourque3 ; 4 ; Vincent Giguè ; re1 ; 2 ; 5 ; 7 ; vincent.giguere@mcgill.ca" class="auth_mail" title="E-mail the corresponding author ; Julie St-Pierre1 ; 2 ; 7 ; julie.st-pierre@mcgill.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPK ; folate ; metabolic reprogramming ; methotrexate ; nuclear receptor
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：2 February 2016
- 年：2016
- 卷：14
- 期：4
- 页码：920-931
- 全文大小：3089 K
文摘
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The PGC-1α/ERRα axis is a key effector of AMPK metabolic reprogramming in cancer
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The PGC-1α/ERRα axis represses folate cycle metabolism
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The PGC-1α/ERRα axis decreases purine biosynthesis
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The PGC-1α/ERRα axis sensitizes cells and tumors to anti-folate therapy