Comparative Outcome Analysis of Children Who Underwent Pyeloplasty for Ureteropelvic Junction Obstruction Associated With or Without Supranormal Differential Renal Function

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• 作者：Mandy Rickard^a ; ^b ; Luis H. Braga^a ; ^b ; ^c ; ^{braga@mcmaster.ca} ; Shreyas Gandhi^b ; John-Paul Oliveria^b ; Jorge Demaria^a ; ^b ; ^c ; Armando J. Lorenzo^d ; ^e
• 刊名：Urology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：99
• 期：Complete
• 页码：210-214
• 全文大小：162 K
• 卷排序：99

文摘

To compare pyeloplasty outcomes in children with and without “supra-normal” differential renal function (SNDRF) defined as >55% differential renal function (DRF) in children with ureteropelvic junction obstruction.MethodsOur prospectively collected pyeloplasty database (2008-2015) was reviewed (n = 151). A total of 140/151 (93%) patients had preoperative renograms and 26/140 (19%) were found to have SNDRF (DRF ≥ 55%). Of 151 patients, 51 (34%) had pre- and postoperative renograms allowing determination of change ≥5% in function. After excluding 2 patients with solitary kidneys, a total of 49 patients defined the study group.ResultsOf 49 patients, 12 had SNDRF and 37 did not. Baseline characteristics were similar including mean age at surgery (47.3 months vs 45.4 months) and time to surgery (8.7 months vs 9.8 months). Mean preoperative anteroposterior diameter was significantly different between groups (23.2 mm vs 31.0 mm; P = .04), but postoperative was similar (9.0 mm vs 12.1 mm; P = .14). Mean preoperative DRF was 60.2% in the SNDRF group vs 44.3% in the non-SNDRF. Mean postoperative DRF was 52.4% and 45.3%, respectively (P = .04). There were 9/12 (75%) SNDRF patients who experienced ≥5% loss in function compared to 2/37 (5%) in the non-SNDRF group (P < .01).ConclusionThree-quarters of SNDRF patients demonstrated a decline of ≥5%DRF postoperatively when compared to non-SNDRF. This finding may not reflect true elevated renal function, but rather hyperfiltration in the setting of obstruction, which—if unrecognized as such—could result in postponing an otherwise beneficial surgical intervention.