Relative contribution of obesity and serum adiponectin to the development of hypertension

详细信息    查看全文

• 作者：Dong-Hyuk Jung ; Jang-Young Kim ; Jong-Koo Kim ; Sang-Baek Koh ; Jong-Ku Park ; Song Vogue Ahn
• 关键词：KoGES-ARIRANG ; the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population ; RIA ; radioimmunoassay ; LDL ; low density lipoprotein cholesterol ; HDL ; high density lipoprotein cholesterol ; TG ; triglycerides ; hs-CRP ; sensitivity C-reactive protein ; CI ; confidence intervals ; NO ; nitric oxide
• 刊名：Diabetes Research and Clinical Practice
• 出版年：January, 2014
• 年：2014
• 卷：103
• 期：1
• 页码：51-56
• 全文大小：448 K

文摘

Aims

The aim of this study was to investigate the association between serum adiponectin level and new-onset hypertension, and the relative contribution of obesity and low serum adiponectin levels to the development of hypertension in normotensive men and women.

Methods

We analyzed 1553 adults (584 men and 969 women) without hypertension, aged 40-70 years, who had participated in a cohort study in both time periods from 2005 to 2008 for baseline and 2008 to 2011 for follow-up. We divided participants into sex-specific tertiles according to serum adiponectin levels. We defined the highest tertile of serum adiponectin as 鈥榟igh adiponectin鈥? Participants were then stratified into four groups: the non-obese with high adiponectin; the non-obese with low adiponectin; the obese with high adiponectin; and the obese with low adiponectin.

Results

During an average of 2.6 years of follow-up, 79 men (13.5%) and 99 women (10.2%) developed hypertension. Low serum adiponectin level was an independent predictor of new-onset hypertension in men (Odds Ratio[OR]: 1.99; 95% CI: 1.03-3.86). The Obese men with low adiponectin had an increased risk of new-onset hypertension compared with the control group (OR: 2.80; 95% CI: 1.35-5.81). In postmenopausal women, the obese subjects with low adiponectin had an increased risk of new-onset hypertension compared with the control group (OR: 2.41; 95% CI 1.16-5.04).

Conclusion

Low serum adiponectin levels were associated with an increased risk of new-onset hypertension in men and postmenopausal women.