The role of noncoding regions of classical swine fever virus C-strain in its adaptation to the rabbit

详细信息    查看全文

• 作者：Chao Li¹ ; Yongfeng Li¹ ; Liang Shen ; Junhua Huang ; Yuan Sun ; Yuzi Luo ; Bibo Zhao ; Chunhua Wang ; Jin Yuan ; Hua-Ji Qiu ; ^{huajiqiu@hvri.ac.cn" class="auth_mail} ; ^{qiuhuaji@163.com" class="auth_mail}
• 关键词：Classical swine fever virus ; C-strain ; Noncoding regions ; Adaptation to the rabbit ; Fever induction ; Replication in the spleen
• 刊名：Virus Research
• 出版年：21 April, 2014
• 年：2014
• 卷：183
• 期：Complete
• 页码：117-122
• 全文大小：802 K

文摘

Classical swine fever (CSF) is a devastating disease of swine caused by classical swine fever virus (CSFV). C-strain, a modified live vaccine against CSF, was developed through hundreds of passages of a highly virulent CSFV in the rabbit in China in the mid-1950s. To identify the role of noncoding regions (NCRs) of C-strain in its adaptation to the rabbit, we generated and evaluated a series of chimeric viruses derived from C-strain and the highly virulent Shimen strain. The results demonstrated that the NCRs of the C-strain were essential for its fever induction in rabbits and the coding region but not NCRs was necessary for its replication in the spleen of rabbits.