The self-crosslinking smart hyaluronic acid hydrogels as injectable three-dimensional scaffolds for cells culture
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- 作者：Shaoquan Bian bian.shaoquan@stu.scu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Mengmeng He 2014226070002@stu.scu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Junhui Sui suijunhui2013@163.com" class="auth_mail" title="E-mail the corresponding author ; Hanxu Cai 2014226070018@stu.scu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yong Sun ; sunyong8702@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jie Liang jie_l88@126.com" class="auth_mail" title="E-mail the corresponding author ; Yujiang Fan ; fan_yujiang@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; yujiang.fan@163.com" class="auth_mail" title="E-mail the corresponding author ; Xingdong Zhang zhangxd@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hydrogel ; Controllable ; Self-crosslinking ; Thiolated hyaluronic acid ; Three-dimensional scaffold
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：140
- 期：Complete
- 页码：392-402
- 全文大小：3877 K
文摘
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Thiolated hyaluronic acid (HA-SH) hydrogel was obtained by a single component and formed by the self-crosslinking of two free thiol groups.
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No chemical additives, cytotoxic crosslinking and byproducts were added and produced in experiment.
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The gelation time, swelling property, mechanical property and intelligent degradation behavior of the hydrogel could be controlled.
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The characterizations of controllable self-crosslinking HA-SH hydrogels has great potential to meet the requirement of biomaterials applied in different fields of biomedicine.