Soft matrices downregulate FAK activity to promote growth of tumor-repopulating cells

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• 作者：Youhua Tan<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>csup><sup> ; sup><sup>1sup> ; Adam Richard Wood<sup>bsup><sup> ; sup><sup>1sup> ; Qiong Jia<sup>asup><sup> ; sup><sup>1sup> ; Wenwen Zhou<sup>asup> ; Junyu Luo<sup>asup> ; Fang Yang<sup>asup> ; Junwei Chen<sup>asup> ; Junjian Chen<sup>asup> ; Jian Sun<sup>bsup> ; Jihye Seong<sup>dsup> ; Arash Tajik<sup>bsup> ; Rishi Singh<sup>bsup> ; Ning Wang<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>nwangrw@illinois.edusup>
• 关键词：Focal adhesion kinase ; Cancer ; Tumor repopulating cell ; Growth ; Matrix stiffness
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：456-462
• 全文大小：1212 K
• 卷排序：483

文摘

FAK activity, mRNA and protein are low in highly tumorigenic cells. FAK is tightly associated with H3K9 methylation and negatively related to the growth of tumor-repopulating cells. Low FAK promotes rather than blocks the growth of highly tumorigenic cells. Matrix stiffness (rigidity) is a key player in regulating the response of the melanoma cells to FAK modulation.