Controlled release of 5-fluorouracil from microporous zeolites
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- 作者：Marios Spanakis ; Nikolaos Bouropoulos ; Dimitrios Theodoropoulos ; Lamprini Sygellou ; Sinead Ewart ; Anastasia Maria Moschovi ; Angeliki Siokou ; Ioannis Niopas ; Kyriakos Kachrimanis ; Vladimiros Nikolakis ; Paul A. Cox ; Ioannis S. Vizirianakis ; Dimitrios G. Fatouros
- 关键词：Zeolites ; Controlled release ; Molecular modeling ; Cytocompatibility
- 刊名：Nanomedicine: Nanotechnology, Biology and Medicine
- 出版年：January, 2014
- 年：2014
- 卷：10
- 期：1
- 页码：197-205
- 全文大小：1305 K
文摘
Zeolite particles with different pore diameter and particle size were loaded with the model anticancer drug 5-fluorouracil. The loaded zeolites were characterized by means of SEM, XRD, DSC, XPS, N2 physisorption and FT-IR. Higher loading of 5-FU was observed for NaX-FAU than BEA. Release studies were carried out in HCl 0.1 N. Release of 5-FU from NaX-FAU showed exponential-type behaviour with the drug fully released within 10 min. In the case of BEA, the kinetics of 5-FU shows a multi-step profile with prolonged release over time. Molecular dynamics simulations showed that diffusion of the drug molecule through the BEA framework is lower than for NaX-FAU due to increased van der Waals interaction between the drug and the framework. The effect of zeolitic particles on the viability of Caco-2 monolayers showed that the NaX-FAU particles cause a reduction of cell viability in a more pronounced way compared with the BEA particles.
From the Clinical Editor
This article describes zeolite-based nanoparticles in generating time-controlled release of 5-FU from zeolite preparations for anti-cancer therapy.