A study of jet-milling and spray-drying process for the physicochemical and aerodynamic dispersion properties of amiloride HCl
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- 作者：Marija Djoki膰a ; Kyriakos Kachrimanisb ; Ljiljana Solomuna ; Jelena Djuri&scaron ; a ; Dragana Vasiljevi膰a ; Svetlana Ibri膰a ; svetlana.ibric@pharmacy.bg.ac.rs" class="auth_mail
- 关键词：PSD ; particle size distribution ; DRIFTS ; diffuse reflectance Fourier transform infrared spectroscopy ; Cv ; cumulative particle volume ; ED ; emitted dose ; FPF ; fine particle fraction ; MMAD ; mass median aerodynamic diameter ; GSD ; geometric standard deviation ; MDIs ; metered dose inhalers ; DPIs ; dry powder inhalers ; EP ; European Pharmacopoeia ; MSLI ; multistage liquid impinger ; ACI ; Andersen cascade impactor ; NGI ; Next generation impactor ; FT-IR ; Fourier transform infrared ; CI ; Carr's compressibility i
- 刊名：Powder Technology
- 出版年：August 2014
- 年：2014
- 卷：262
- 期：Complete
- 页码：170-176
- 全文大小：952 K
文摘
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We examine jet-milling effect on physicochemical properties of particles.
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We examine jet-milling effect on aerodynamic dispersion properties of particles.
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Comparison of jet-milling effect with spray-drying.
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Jet-milling is an appropriate technique to prepare particles for DPI formulations.