Novel DOCK2-selective inhibitory peptide that suppresses B-cell line migration

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• 作者：Kotaro Sakamoto ; ¹ ; ^{koutarou.sakamoto@takeda.com} ; Yusuke Adachi¹ ; Yusaku Komoike ; Yusuke Kamada ; Ryokichi Koyama ; Yasunori Fukuda ; Akito Kadotani ; Taiji Asami ; Jun-ichi Sakamoto
• 关键词：Peptide ; DOCK2 ; PPI ; CPP ; Cell migration ; Phage display
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：183-190
• 全文大小：1575 K
• 卷排序：483

文摘

We discovered the first DOCK2-selective inhibitory peptides. These peptides had subnanomolar binding- and inhibition-activities in cell-free assays. These peptides inhibited migration in human B lymphocyte MINO cell.