PB2 substitutions V598T/I increase the virulence of H7N9 influenza A virus in mammals

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• 作者：Meng Hu^a ; Shuofeng Yuan^a ; Ke Zhang^a ; Kailash Singh^b ; Qiang Ma^c ; Jie Zhou^a ; ^d ; Hin Chu^a ; ^d ; ^{hinchu@hku.hk} ; Bo-Jian Zheng^a ; ^d ; ^e ; ^f ; ^{bzheng@hkucc.hku.hk}
• 关键词：Influenza A virus ; PB2 ; PB2-K389R ; PB2-V598T/I ; Virulence
• 刊名：Virology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：501
• 期：Complete
• 页码：92-101
• 全文大小：1229 K
• 卷排序：501

文摘

Substitutions at positions PB2-389 and -598 were identified with potential effect on virus pathogenicity. PB2-K389R and -V598T/I substitutions enhanced virus growth capacity in human and mammalian cells. The PB2-K389R and -V598T/I increased virus transcription/replication by producing more viral RNAs in human cells. The PB2-K389R and -V598T/I substitutions elevated the polymerase activity in human cells. The PB2-V598T/I substitutions increased virus replication and virulence in mice.