Comparing methods for full versus single technology appraisal: A case study of docetaxel and paclitaxel for early breast cancer

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• 作者：Eva Kaltenthaler ; Paul Tappenden ; Andrew Booth ; Ron Akehurst
• 关键词：NICE ; HTA ; Taxanes ; Breast neoplasms ; Documentary analysis ; Rapid appraisal
• 刊名：Health Policy
• 出版年：2008
• 出版时间：September 2008
• 年：2008
• 卷：87
• 期：3
• 页码：389-400
• 全文大小：133 K

文摘

class=""h4"">Objective

The aim of this study is to compare and contrast the reports of the rapid National Institute for Health and Clinical Excellence (NICE) single technology (STA) process with the full Health Technology Assessment Report (TAR) for the same technologies (docetaxel and paclitaxel for the adjuvant treatment of early breast cancer).

class=""h4"">Methods

Documentary analysis was used to compare three reports. A data extraction form was developed to record information on the decision problem addressed in each report, literature searching methods, the clinical effectiveness review, cost-effectiveness analysis, conclusions and issues of concern.

class=""h4"">Results

The decision problems and search strategies for the STAs differed from those reported in the TAR. Not all trials of clinical effectiveness included in the TAR were reported by manufacturers. The methods and assumptions used to assess the cost-effectiveness of the technologies were generally similar between reports, although only one common health economic comparison was presented across the three reports. The TAR supports the STA results for docetaxel but suggested that the manufacturer's cost-effectiveness estimates for paclitaxel were highly optimistic.

class=""h4"">Conclusions

Although the STA process provides the opportunity for rapid appraisal of new technologies, there remains uncertainty concerning the extent to which STAs adequately address the specific decision problem under consideration.