Prognosticators and outcomes of patients with renal cell carcinoma and adjacent organ invasion treated with radical nephrectomy
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- 作者：Leonardo D. Borregales ; M.D.a ; Dae Y. Kim ; M.D. ; Ph.D.a ; Angie L. Staller ; M.D.a ; Wei Qiao ; M.S.b ; Arun Z. Thomas ; M.D.a ; Mehrad Adibi ; M.D.a ; Pheroze Tamboli ; M.D.c ; Kanishka Sircar ; M.D.c ; Eric Jonasch ; M.D.d ; Nizar M. Tannir ; M.D. ; F.A.C.P.d ; Surena F. Matin ; M.D. ; F.A.C.S.a ; Christopher G. Wood ; M.D. ; F.A.C.S.a ; Jose A. Karam ; M.D. ; F.A.C.S.a ; JAKaram@mdanderson.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：T4 ; Renal cell carcinoma ; Predictors ; Nephrectomy ; Surgery
- 刊名：Urologic Oncology: Seminars and Original Investigations
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：34
- 期：5
- 页码：237.e19-237.e26
- 全文大小：328 K
文摘
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In patients with pT4 RCC, who underwent RN, we found that abnormal preoperative LDH and ALP, metastases at diagnosis, pN1, and sarcomatoid dedifferentiation were independent predictors of survival.
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Accurate preoperative identification of patients with pT4 disease remains difficult. In our study, only 68.9% were predicted to have clinical T4 on preoperative imaging.
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Although patients with pT4M1 disease had a median CSS of 8 months, those with pT4M0 had median CSS of 37 months, indicating a benefit to surgical resection in patients with nonmetastatic disease.