Percentage of sarcomatoid component as a prognostic indicator for survival in renal cell carcinoma with sarcomatoid dedifferentiation
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- 作者：Mehrad Adibi ; M.D.a ; Arun Z. Thomas ; M.D.a ; Leonardo D. Borregales ; M.D.a ; Megan M. Merrill ; D.O.a ; 1 ; Rebecca S. Slack ; M.S.b ; Hsiang-Chun Chen ; M.S.b ; Kanishka Sircar ; M.D.c ; Paari Murugan ; M.D.c ; Pheroze Tamboli ; M.D.c ; Eric Jonasch ; M.D.d ; Nizar M. Tannir ; M.D. ; F.A.C.P.d ; Surena F. Matin ; M.D. ; F.A.C.S.a ; Christopher G. Wood ; M.D. ; F.A.C.S.a ; Jose A. Karam ; M.D. ; F.A.C.S.a ; JAKaram@mdanderson.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sarcomatoid ; Renal cell carcinoma ; Percentage ; Nephrectomy ; Recursive partitioning analysis
- 刊名：Urologic Oncology: Seminars and Original Investigations
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：33
- 期：10
- 页码：427.e17-427.e23
- 全文大小：414 K
文摘
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Univariate Recursive Partioning Analysis (RPA) identified a Percentage Sarcomatoid Component (PSC) cutpoint of 10% as prognostically significant in the general study cohort.
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Multivariate RPA revealed that tumor size (cutpoint of 10cm), presence of metastatic disease, and PSC (cutpoint of 40%) were significantly associated with overall survival.
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Among 4 identified groups, patients with localized disease and tumor size ≤10cm were most likely to be alive at 1 year (89%), while patients with metastatic disease and PSC>40% were least likely to be alive at 1 year (28%; p<0.001)