A spherical harmonics intensity model for 3D segmentation and 3D shape analysis of heterochromatin foci
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- 作者：Simon Eck ; a ; simon.eck@bioquant.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Stefan Wö ; rza ; s.woerz@dkfz.de" class="auth_mail" title="E-mail the corresponding author ; Katharina Mü ; ller-Ottb ; Matthias Hahnc ; Andreas Biesdorfa ; Gunnar Schottac ; Karsten Rippeb ; Karl Rohra ; k.rohr@dkfz.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：3D parametric intensity model ; Spherical harmonics ; Pericentric heterochromatin ; Confocal light microscopy
- 刊名：Medical Image Analysis
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：32
- 期：Complete
- 页码：18-31
- 全文大小：4972 K
文摘
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Model-based approach for automatic 3D segmentation of heterochromatin foci.
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Novel 3D parametric intensity model based on a spherical harmonics expansion.
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3D shape analysis of heterochromatin by exploiting the segmentation result.
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Quantitative evaluation based on synthetic and real confocal microscopy image data.
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The approach copes well with high noise levels and various 3D shapes and sizes.