Estimation of paracrine signaling using quantitative RT-PCR from multiple patchy lesion samples

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• 作者：Shuang Jiao ; Haruo Hanawa ; ^{hanawa@med.niigata-u.ac.jp} ; Tomoyasu Suzuki ; Ying Hua Hu ; Kaori Yoshida ; Minako Ogura ; Yukako Ohno ; Masahiro Ito ; Takeshi Kashimura ; Hiroaki Obata ; Makoto Kodama
• 关键词：Paracrine ; Cytokine ; Inflammation ; Organ injury ; Quantitative RT-PCR ; Correlation analysis
• 刊名：Molecular and Cellular Probes
• 出版年：2013
• 出版时间：April, 2013
• 年：2013
• 卷：27
• 期：2
• 页码：109-113
• 全文大小：306 K

文摘

We investigated whether correlations between mRNA levels of cytokines versus other proteins from patchy lesion could estimate cytokine paracrine signaling in?vivo. Experiments with rat experimental autoimmune myocarditis (EAM), a patchy myocarditis model, indicated IL-1 and other protein levels were correlated, indicating paracrine signaling pathways in?vivo.