Pro- and anti-inflammatory cytokines in the CSF of patients with Creutzfeldt–Jakob disease

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• 作者：Katharina Stoeck ; Monika Bodemer and Inga Zerr
• 关键词：Creutzfeldt– ; Jakob disease (CJD) ; Prion disease ; Cerebrospinal fluid (CSF) ; Cytokines ; Chemokines
• 刊名：Journal of Neuroimmunology
• 出版年：2006
• 出版时间：March 2006
• 年：2006
• 卷：172
• 期：1-2
• 页码：175-181
• 全文大小：188 K

文摘

We investigated cerebrospinal fluid (CSF) samples from patients with Creutzfeldt–Jakob disease (CJD) and other neurological diseases.

Concentrations of pro- and anti-inflammatory cytokines IL-1β, IL-6, IL-8, IL-12, TNF-α and TGF-β 2 were determined in CSF using ELISA.

Significant changes were found for IL-8 and TGF-β 2. IL-8 levels were elevated in the CSF of CJD patients. Of interest, the increase was significant to other dementia and to controls. In contrast, TGF-β 2 was significantly decreased in CSF of CJD compared to all groups. IL-1β, IL-12 and TNF-α could not be detected in CSF or in case of IL-6 in only low concentrations without significant difference.