Novel antifungal agents: Triazolopyridines as inhibitors of β-1,6-glucan synthesis
详细信息 查看全文
- 作者：Jun-ichi Kuroyanagi ; Kazuo Kanai ; Yuuichi Sugimoto ; Tetsunori Fujisawa ; Chikanori Morita ; Takashi Suzuki ; Katsuhiro Kawakami ; Makoto Takemura
- 关键词：Antifungal activity ; Triazolopyridine ; β ; -1 ; 6-Glucan ; Candida species
- 刊名：Bioorganic and Medicinal Chemistry
- 出版年：2010
- 出版时间：15 August 2010
- 年：2010
- 卷：18
- 期：16
- 页码：5845-5854
- 全文大小：626 K
文摘
Preparations and in vitro antifungal activities of triazolopyridines, imidazopyridines, and a pyrazolopyridine were reported. Among those scaffolds, triazolopyridine was found to be the specific inhibitor of the synthesis of β-1,6-glucan, an essential component of the fungal cell wall, and to show potent antifungal activities against several Candida species.