Preparation, characterization, and in vitro anti-inflammatory evaluation of novel water soluble kamebakaurin/hydroxypropyl-β-cyclodextrin inclusion complex

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• 作者：Aun Raza^a ; Huifang Sun^a ; Shumaila Bano^b ; Yingying Zhao^a ; Xiuquan Xu^a ; Jian Tang^a ; ^{jt.u@hotmail.com}
• 关键词：Kamebakaurin ; Hydroxypropyl-β-cyclodextrin ; Inclusion complex ; Solubility ; Characterization ; Anti-inflammatory
• 刊名：Journal of Molecular Structure
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：1130
• 期：Complete
• 页码：319-326
• 全文大小：926 K
• 卷排序：1130

文摘

The kaurane diterpene has poor water solubility and this limits its utilization. Aim of the KA/HP-β-CD complex was solubility enhancement by freeze drying method. Phase solubility study showed linear relationship (AL type) with 1:1 stoichiometry. FTIR, SEM, PXRD and 1H NMR confirmed the interaction between KA and HP-β-CD. In vitro anti-inflammatory activity of KA/HP-β-CD complex was investigated.