Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes
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- 作者：Kayo Kuroyanagi ; Min-Sook Kang ; Tsuyoshi Goto ; Shizuka Hirai ; Kana Ohyama ; Tatsuya Kusudo ; Rina Yu ; Masamichi Yano ; Takao Sasaki ; Nobuyuki Takahashi ; Teruo Kawada
- 关键词：Auraptene ; Adipocyte ; PPAR ; Adiponectine ; MCP-1 ; Inflammation ; Metabolic syndrome
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2008
- 出版时间：1 February 2008
- 年：2008
- 卷：366
- 期：1
- 页码：219-225
- 全文大小：162 K
文摘
Citrus fruit compounds have many health-enhancing effects. In this study, using a luciferase ligand assay system, we showed that citrus auraptene activates peroxisome proliferator-activated receptor (PPAR)-α and PPARγ. Auraptene induced up-regulation of adiponectin expression and increased the ratio of the amount of high-molecular-weight multimers of adiponectin to the total adiponectin. In contrast, auraptene suppressed monocyte chemoattractant protein (MCP)-1 expression in 3T3-L1 adipocytes. Experiments using PPARγ antagonist demonstrated that these effects on regulation of adiponectin and MCP-1 expression were caused by PPARγ activations. The results indicate that auraptene activates PPARγ in adipocytes to control adipocytekines such as adiponectin and MCP-1 and suggest that the consumption of citrus fruits, which contain auraptene can lead to a partial prevention of lipid and glucose metabolism abnormalities.