Assessment of hand-held Raman instrumentation for in situ
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- 作者：Camilla Ricci ; Leonard Nyadong ; Felicia Yang ; Facundo M. Fern ; ez ; Christopher D. Brown ; Paul N. Newton ; Sergei G. Kazarian
- 关键词：Counterfeit drugs ; Portable Raman spectroscopy ; Mass spectrometry ; Desorption electrospray ionization ; Direct analysis in real-time ; Malaria
- 刊名：Analytica Chimica Acta
- 出版年：2008
- 出版时间：15 August 2008
- 年：2008
- 卷：623
- 期：2
- 页码：178-186
- 全文大小：887 K
文摘
Pharmaceutical counterfeiting has become a significant public health problem worldwide and new, rapid, user-friendly, reliable and inexpensive methods for drug quality screening are needed. This work illustrates the chemical characterization of genuine and fake artesunate antimalarial tablets by portable Raman spectroscopy and validation by FT-Raman spectroscopy and ambient mass spectrometry. The applicability of a compact and robust portable Raman spectrometer (TruScan™) for the in situ chemical identification of counterfeit tablets is reported.