Prevalence and distribution of coronary calcium in asymptomatic Japanese subjects in lung cancer screening computed tomography

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• 作者：Yuki Ohmoto-Sekine ; MD^a ; ^{yoomoto@toranomon.gr.jp" class="auth_mail" title="E-mail the corresponding author} ; Ryoko Yanagibori ; PhD^b ; Kazuhisa Amakawa ; MD^a ; Makiko Ishihara ; MD^c ; Hiroshi Tsuji ; MD^a ; Kyoko Ogawa ; MD^a ; Rieko Ishimura ; MD^d ; Sugao Ishiwata ; MD ; FJCC^d ; Minoru Ohno ; MD ; FJCC^d ; Tetsu Yamaguchi ; MD ; FJCC^d ; Yasuji Arase ; MD^a
• 关键词：Coronary artery calcium ; Epidemiology ; Ethics ; Risk factor
• 刊名：Journal of Cardiology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：67
• 期：5
• 页码：449-454
• 全文大小：390 K

文摘

Coronary artery calcium (CAC) is associated with a risk of coronary heart disease. The prevalence and distribution of the CAC score have been examined in Western countries, but few studies have been performed in Asia, and especially in Japan. The goal of this study was to investigate CAC scores in an asymptomatic Japanese population.

Methods

CAC score and risk factors were analyzed in 1834 asymptomatic subjects who underwent lung cancer screening computed tomography.

Results

CAC was present in 26.9% of all the subjects, 29.8% of the males, and 17.1% of the females. In all age groups, the CAC score was higher in males. In multivariate analysis, male gender [odds ratio (OR) 2.461, 95% confidence interval (CI) 1.361–4.452, p = 0.002], aging (OR 1.102, 95% CI 1.081–1.123, p < 0.001), dyslipidemia (OR 1.740, 95% CI 1.216–2.490, p = 0.002), and fasting glucose (OR 1.008, 95% CI 1.002–1.015, p = 0.012) were significantly associated with a CAC score >100.

Conclusion

The results of this study provide a pattern of CAC distribution based on age and gender in asymptomatic Japanese subjects. This pattern was similar to that in Western countries, although the absolute CAC scores were lower. High CAC scores were associated with male gender, aging, dyslipidemia, and fasting glucose.