Lupus erythematosus profundus (lupus panniculitis) induced by interferon-β in a multiple sclerosis patient
详细信息 查看全文
- 作者：Takahisa Gono ; Masayuki Matsuda ; Yasuhiro Shimojima ; Kazuma Kaneko ; Hiroshi Murata ; Shu-ichi Ikeda
- 关键词：Interferon-β ; Lupus erythematosus profundus ; Multiple sclerosis
- 刊名：Journal of Clinical Neuroscience
- 出版年：2007
- 出版时间：October 2007
- 年：2007
- 卷：14
- 期：10
- 页码：997-1000
- 全文大小：275 K
文摘
We report a patient with multiple sclerosis (MS) who developed subcutaneous nodules on the face, shoulders and extremities while being treated with interferon (IFN)-β-1b. These nodules fluctuated in parallel with myelopathy, and were diagnosed as lupus erythematosus profundus (LEP) based on histopathological findings. The patient showed no relapse of either neurological symptoms or subcutaneous nodules after cessation of IFN-β-1b. This agent can cause induration and necrosis in the sites of injection but also systemic skin lesions such as LEP ascribable to its immunomodulatory effects.