A method for quantification of serum tenascin-X by nano-LC/MS/MS
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- 作者：Kazuo Yamadaa ; b ; Atsushi Watanabec ; d ; Haruo Takeshitab ; Ken-ichi Matsumotoa ; matumoto@med.shimane-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nano-LC/MS/MS ; SRM/MRM ; Tenascin-X ; Ehlers-Danlos syndrome ; Stable isotope-labeled peptide
- 刊名：Clinica Chimica Acta
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：459
- 期：Complete
- 页码：94-100
- 全文大小：365 K
文摘
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A method was developed for quantification of sTNX using nano-LC/MS/MS.
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Excellent linear regressions were achieved with LOQ in nanogram per milliliter range.
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This method will be useful for diagnosis and risk stratification of EDS caused by TNX deficiency and haploinsufficiency.