Cerebrospinal fluid biomarkers for prognosis of long-term cognitive treatment outcomes in patients with idiopathic normal pressure hydrocephalus
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- 作者：Madoka Nakajima ; madoka66@juntendo.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Masakazu Miyajima mmasaka@juntendo.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Ikuko Ogino i-ogino@juntendo.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Chihiro Akiba chihi-rocket@hotmail.co.jp" class="auth_mail" title="E-mail the corresponding author ; Hidenori Sugano debo@juntendo.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Takeshi Hara thara79nouge@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Keiko Fusegi keiko-fusegi@nifty.com" class="auth_mail" title="E-mail the corresponding author ; Kostadin Karagiozov kostadinkaragiozov@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Hajime Arai harai@juntendo.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：A尾 ; amyloid-beta ; iNPH ; idiopathic normal pressure hydrocephalus ; LPS ; lumboperitoneal shunting ; iNPHGS ; iNPH Grading Scale ; MMSE ; Mini Mental State Examination ; FAB ; frontal assessment battery ; TMT-A ; trail making test part A ; mRS ; modified Rankin Scale ; NC ; normal control ; LP ; lumbar puncture ; sAPP ; soluble amyloid precursor protein ; sAPP伪 ; sAPP alpha ; sAPP尾 ; sAPP beta ; APP ; amyloid precursor protein ; AUC ; area under the curve ; ROC ; receiver operating characteristic ; IQR ; interquartile range
- 刊名：Journal of the Neurological Sciences
- 出版年：2015
- 出版时间：15 October 2015
- 年：2015
- 卷：357
- 期：1-2
- 页码：88-95
- 全文大小：897 K
文摘
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Shunt reservoir and lumbar CSF biomarkers were compared in 36 iNPH patients.
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P-tau, A尾1–38/A尾1–42, and A尾1–42/p-tau in the preoperative CSF can be biomarkers.
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Cystatin C and L-PGDS increased after CSF circulation improved after LPS.
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Cognitive prognosis improved after synthesis switched from A尾1–42 to A尾1–38.