A hydrogen peroxide safety valve: The reversible phosphorylation of catalase from the freeze-tolerant North American wood frog, Rana sylvatica
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- 作者：Neal J. Dawson1 ; Kenneth B. Storey ; kenneth_storey@carleton.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Akt ; Protein kinase B ; AMPK ; Adenosine monophosphate-activated protein kinase ; cAMP ; Cyclic adenosine monophosphate ; CAMK ; Calmodulin dependent kinase ; Cdc2 ; Cyclin dependent kinase 1 ; Cdk5 ; Cyclin dependent kinase 5 ; cGMP ; Cyclic guanidine monophosphate ; DEAE ; + ; ; Diethylaminoethyl cellulose ; DEPC ; Diethylpyrocarbonate ; DTT ; Dithiothreitol ; EDTA ; Ethylene diamine tetraacetic acid ; EGFR ; Epidermal growth factor receptor tyrosine kinase ; EGTA ; Ethylene glycol tetraacetic acid ; Erk1 ; Mito
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：1860
- 期：3
- 页码：476-485
- 全文大小：1043 K
文摘
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CAT from frozen frogs show changes in V
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CAT from frozen frogs show increased phosphorylation in comparison to control frogs.
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CAT from R. sylvatica can be phosphorylated or dephosphorylated by endogenous kinases/phosphatases in vitro.
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Freeze-induced changes adjust CAT function to account for rising oxidative stressors.