APC/C and SCFcyclin F Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry
详细信息 查看全文
- 作者：Rajarshi Choudhury1 ; Thomas Bonacci1 ; Anthony Arceci1 ; Debojyoti Lahiri2 ; Christine A. Mills1 ; Jennifer L. Kernan1 ; Timothy B. Branigan3 ; James A. DeCaprio3 ; Daniel J. Burke2 ; Michael J. Emanuele1 ; 4 ; emanuele@email.unc.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：20 September 2016
- 年：2016
- 卷：16
- 期：12
- 页码：3359-3372
- 全文大小：3291 K
文摘
- •
SCFcyclin F and APC/CCdh1 constitute a reciprocal feedback circuit
- •
Cyclin F is targeted for ubiquitylation and degradation by APC/CCdh1 in G1 phase
- •
Cdh1 is targeted for ubiquitylation and degradation by SCFcyclin F in S-phase
- •
Cyclin F contributes to Cdh1 degradation, APC/C inactivation, and S-phase entry