Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity
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- 作者：Evelyne Beerling1 ; 4 ; Danië ; lle Seinstra1 ; 4 ; Elzo de Wit1 ; 3 ; Lennart Kester1 ; Daphne van der Velden3 ; Carrie Maynard1 ; Ronny Schä ; fer1 ; Paul van Diest2 ; Emile Voest3 ; Alexander van Oudenaarden1 ; Nienke Vrisekoop1 ; 5 ; n.vrisekoop@umcutrecht.nl" class="auth_mail" title="E-mail the corresponding author ; Jacco van Rheenen1 ; j.vanrheenen@hubrecht.eu" class="auth_mail" title="E-mail the corresponding author
- 关键词：cancer ; epithelial-to-mesenchymal transition (EMT) ; intravital microscopy
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：14
- 期：10
- 页码：2281-2288
- 全文大小：3934 K
文摘
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Direct evidence of EMT obtained in unperturbed breast tumors by real-time visualization
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EMT exists in breast tumors without experimentally altering EMT inducers
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Tumor cells that underwent EMT are the migratory cells within a tumor
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Outgrowth potential differences between states are irrelevant due to plasticity