Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche

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• 作者：Shilu Amin¹ ; ² ; Roel Neijts¹ ; ² ; Salvatore Simmini¹ ; Carina van Rooijen¹ ; Sander C. Tan¹ ; Lennart Kester¹ ; Alexander van Oudenaarden¹ ; Menno P. Creyghton¹ ; Jacqueline Deschamps¹ ; ³ ; ^{j.deschamps@hubrecht.eu}
• 关键词：mouse embryonic development ; elongation of the anteroposterior axis ; genetics of posterior tissue generation ; axial progenitors ; regulatory elements
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：20 December 2016
• 年：2016
• 卷：17
• 期：12
• 页码：3165-3177
• 全文大小：4014 K
• 卷排序：17

文摘

Expression of Cdx2 is essential for posterior neuro-mesodermal axial progenitors Cdx2/T Brachyury double mutants are more severely truncated than single mutants Cdx2 and T Brachyury directly co-activate genes of the Wnt and Fgf signaling pathways The genetic network driven by Cdx/Hox and T Brachyury establishes differential axial growth