Symbiotic gut commensal bacteria act as host cathepsin S activity regulators
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- 作者：Alex Steimlea ; 1 ; Kerstin Gronbacha ; 1 ; Brigitte Beifussa ; Andrea Schä ; fera ; Robin Harmeninga ; Annika Bendera ; Jan Kevin Maerza ; Anna Langea ; Lena Michaelisa ; Andreas Maurerc ; Sarah Menza ; Kathy McCoyd ; Ingo B. Autenrietha ; Hubert Kalbacherb ; Julia-Stefanie Fricka ; julia-stefanie.frick@med.uni-tuebingen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Inflammatory bowel disease ; Cathepsin S ; Microbiota ; Immunotherapy ; Protease regulation ; Autoimmune disease
- 刊名：Journal of Autoimmunity
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：82-95
- 全文大小：2518 K
文摘
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Symbiotic gut commensals protect from colitis induction.
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Prevention of colitis is caused by regulation of cathepsin S activity.
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Inhibition of cathepsin S activity is mediated by cystatin C.
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Symbiont-induced low intracellular ROS levels are responsible for inhibition.