Strategies to Reconstruct a Functional Urethral Substitute by Self-assembly Method

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• 作者：Amé ; lie Morissette^a ; ^b ; Annie Imbeault^b ; Valé ; rie Cattan^a ; ^b ; Geneviè ; ve Bernard^a ; Guillaume Taillon^a ; Sté ; phane Chabaud^a ; Sté ; phane Bolduc^a ; ^b ; ^{stephane.bolduc@fmed.ulaval.ca}
• 关键词：Type your keywords here ; separated by semicolons
• 刊名：Procedia Engineering
• 出版年：2013
• 出版时间：2013
• 年：2013
• 卷：59
• 期：Complete
• 页码：193-200
• 全文大小：342 K

文摘

Current urethral reconstruction procedures present many related complications. Moreover, the availability of urologic tissue is limited. Free of exogenous biomaterials, synthetic polymers or acellular matrices, a new tissue engineering technology has been optimized. This technique is known as self-assembly. The fibroblasts produce and assemble their own extracellular matrix to form a tissue very similar to native one. Goals are: to reconstruct a human urethral substitute containing a mature urothelium and a functional vascular network. The same substitute will also be produced using rabbit cells to allow autologous in vivo grafting.