文摘
CD4+ T cell characterization with or without CD28 and NKG2D in cervical cancer is proposed. CD4+CD28null T cells, many of them NKG2D+, are expanded in selected cervical cancer samples. The lack of immunoregulatory markers is a signature for the CD4+CD28null T cells. Strong perforin expression is a characteristic of the CD4+CD28null T cell population. The presence of NKG2D enhances the expression of perforin in CD4+CD28null T cells.