The interaction of a Trypanosoma brucei KH-domain protein with a ribonuclease is implicated in ribosome processing
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- 作者：Smriti Kala<sup>asup><sup> ; sup><sup>1sup> ; Vaibhav Mehta<sup>asup><sup> ; sup><sup>csup><sup> ; sup><sup>1sup> ; Chun Wai Yip<sup>asup> ; Houtan Moshiri<sup>asup><sup> ; sup><sup>csup> ; Hamed Shateri Najafabadi<sup>asup> ; Ruoyu Ma<sup>asup> ; Najmeh Nikpour<sup>asup> ; Sara L. Zimmer<sup>bsup> ; Reza Salavati<sup>asup><sup> ; sup><sup>csup><sup> ; sup><sup>reza.salavati@mcgill.casup>
- 关键词：Trypanosome ; Ribosomal RNA ; 18S rRNA ; RNA-binding ; Nuclease
- 刊名：Molecular and Biochemical Parasitology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：211
- 期：Complete
- 页码：94-103
- 全文大小：1515 K
- 卷排序：211
文摘
Characterized the two essential factors for 20S pre-rRNA processing in T. brucei. Silencing either factor inhibits processing of the 20S pre-rRNA and parasite growth. Cleavage specificity is determined by a non-ribonuclease protein factor.