7α-Alkylation and 7,7-bis-alkylation of 20-hydroxyecdysone with propargyl bromide in a lithium-ammonia solution and catalytic reductive spirocyclization of 7,7-bis(2-propyn-1-yl)-14-deoxy-Δ8(14)-20-hydroxyecdysone
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- 作者：Ilgiz V. Galyautdinov ; ilgizphd@mail.ru" class="auth_mail" title="E-mail the corresponding author ; Zarema R. Khairullina ; Valery P. Sametov ; Zabir S. Muslimov ; Leonard M. Khalilov ; Victor N. Odinokov
- 关键词：20-Hydroxyecdysone ; Alkylation ; Bis-alkylation ; Propargyl bromide ; Lithium&ndash ; ammonia solution ; Spirocyclization
- 刊名：Steroids
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：107
- 期：Complete
- 页码：121-127
- 全文大小：585 K
文摘
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A convenient method for spirocyclization of 20-hydroxyecdysone was proposed.
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For the first time an alkynylation of 20-hydroxyecdysone with propargyl bromide was accomplished.
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The structures of compounds were confirmed by 1D and 2D NMR analysis and MALDI TOF.