PLA micro- and nano-particles

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• 作者：Byung Kook Lee ; Yeonhee Yun ; Kinam Park ; ^{kpark@purdue.edu}
• 关键词：PLA ; Micro-particles ; Nano-particles ; Fabrication methods ; Drug delivery system
• 刊名：Advanced Drug Delivery Reviews
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：107
• 期：Complete
• 页码：176-191
• 全文大小：2825 K
• 卷排序：107

文摘

Poly(d,l-lactic acid) (PLA) has been widely used for various biomedical applications for its biodegradable, biocompatible, and nontoxic properties. Various methods, such as emulsion, salting out, and precipitation, have been used to make better PLA micro- and nano-particle formulations. They are widely used as controlled drug delivery systems of therapeutic molecules, including proteins, genes, vaccines, and anticancer drugs. Even though PLA-based particles have challenges to overcome, such as low drug loading capacity, low encapsulation efficiency, and terminal sterilization, continuous innovations in particulate formulations will lead to development of clinically useful formulations.