Chondroma arising from the spinal dura mater at the thoracic level: A case report with molecular analysis

详细信息    查看全文

• 作者：Masaya Miyazaki^a ; ^{masaya.myzk@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Keita Yashiro^b ; Mishie Tanino^c ; Shinya Tanaka^c ; Yasunori Fujioka^a ; ^c ; ^{yasunori.fujioka@nikko-kinen.or.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Chondroma ; Spinal dura mater ; IDH1/2
• 刊名：Pathology - Research and Practice
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：212
• 期：9
• 页码：838-841
• 全文大小：1453 K

文摘

Chondromas are benign tumors that can be found at several sites in the body, while those arising from the dura mater are extremely rare. Among them, although chondromas arising from the cranial dura mater have been reported, those arising from the spinal dura mater have not been reported in the literature to date.

A 66-year-old woman presented with right-sided continuous backache which she had developed recently. After detailed examinations, an epidural tumor at the thoracic level was detected. The patient underwent surgery and a total en-bloc resection was accomplished. From the clinical and pathological findings, the tumor was revealed as chondroma arising from the spinal dura mater.

A recent comprehensive study has identified the isocitrate dehydrogenase 1 (IDH1) and IDH2 mutations in conventional central and periosteal cartilaginous tumors, and it has subsequently been analyzed in intracranial chondrosarcoma and chondroma, including chondroma of the convexity dura mater. Herein, we describe a novel case of chondroma arising from the spinal dura mater, with mutation analysis of IDH1 and IDH2 both of which revealed wild-type.