Recombinant sialidase NanA (rNanA) cleaves 伪2-3 linked sialic acid of host cell surface N-linked glycoprotein to promote Edwardsiella tarda infection
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- 作者：Petros Kingstone Chigwechokhaa ; b ; Mutsumi Tabatac ; Sayaka Shinyoshic ; Kazuki Oishic ; Kyosuke Arakia ; c ; Masaharu Komatsua ; c ; Takao Itakuraa ; c ; Kazuhiro Shiozakia ; c ; shiozaki@fish.kagoshima-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Edwardsiella tarda ; NanA ; Infection ; Sialidase ; 伪2-3 sialo-glycoprotein ; Mannose
- 刊名：Fish & Shellfish Immunology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：47
- 期：1
- 页码：34-45
- 全文大小：1236 K
文摘
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Desialylation is essential for the initial steps of Edwardsiella tarda infection.
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Sialidase NanA preferentially cleaves 伪2-3 sialic acid of N-linked glycoprotein.
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Glycoproteins not glycolipids are actual target in E. tarda infection.
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E. tarda potentially recognizes and binds to mannose chains during infection.