Lysosomal localization of Japanese medaka (Oryzias latipes) Neu1 sialidase and its highly conserved enzymatic profiles with human
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- 作者：Sena Ryuzonoa ; Ryo Takasea ; Kazuki Oishia ; Asami Ikedaa ; Petros Kingstone Chigwechokhaa ; b ; Aki Funahashia ; b ; Masaharu Komatsua ; b ; Taeko Miyagic ; Kazuhiro Shiozakia ; b ; shiozaki@fish.kagoshima-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：HA ; hemagglutinin ; MU-NANA ; methylumbelliferyl-N-acetyl neuraminic acid ; ORF ; open reading frame ; rpl-7 ; ribosomal protein 7
- 刊名：Gene
- 出版年：2016
- 出版时间：10 January 2016
- 年：2016
- 卷：575
- 期：2
- 页码：513-523
- 全文大小：1681 K
文摘
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Medaka neu1 gene was cloned from the brain and its ORF was consisted of 1,182 bp.
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Medaka cathepsin A was essential for medaka Neu1 activation same as human.
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Neu1 enzymatic profiles and subcellular localization were conserved with human.
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Similarity of medaka and human Neu1 suggests medaka's possibility as model animal.