Dysfunction in macrophage toll-like receptor signaling caused by an inborn error of cationic amino acid transport
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- 作者：Johanna Kurkoa ; johanna.kurko@utu.fi" class="auth_mail" title="E-mail the corresponding author ; Mari Vä ; hä ; -Mä ; kilä ; b ; mari.vaha-makila@utu.fi" class="auth_mail" title="E-mail the corresponding author ; Maaria Tringhama ; maaria.tringham@utu.fi" class="auth_mail" title="E-mail the corresponding author ; Laura Tannera ; c ; laura.tanner@utu.fi" class="auth_mail" title="E-mail the corresponding author ; Sari Paavanen-Huhtalab ; paavanen@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Maiju Saarinenb ; d ; maiju.m.saarinen@utu.fi" class="auth_mail" title="E-mail the corresponding author ; Kirsti Nä ; ntö ; -Salonenb ; kirsti.nanto-salonen@tyks.fi" class="auth_mail" title="E-mail the corresponding author ; Olli Simellb ; olli.simell@utu.fi" class="auth_mail" title="E-mail the corresponding author ; Harri Niinikoskib ; harri.niinikoski@tyks.fi" class="auth_mail" title="E-mail the corresponding author ; Juha Mykkä ; nenb ; e ; juha.mykkanen@utu.fi" class="auth_mail" title="E-mail the corresponding author
- 关键词：LPI ; lysinuric protein intolerance ; CAA ; cationic amino acid ; SLE ; systemic lupus erythematosus ; PAP ; pulmonary alveolar proteinosis ; PAMP ; pathogen-associated molecular pattern ; eGFR ; estimated glomerular filtration rate
- 刊名：Molecular Immunology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：67
- 期：2
- 页码：416-425
- 全文大小：913 K
文摘
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Hereditary cationic amino acid transport defect impairs macrophage TLR signaling.
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TNF-α, IL-12 and IL-1RA levels are elevated after TLR2/1 and TLR4 induction in LPI.
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IFN-α secretion is reduced by LPI macrophages after TLR9 activation.
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NO secretion by LPI macrophages is decreased, indicating arginine deficiency.
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Inflammatory chemokine levels of CXCL8, CXCL9 and CXCL10 are elevated in LPI plasma.