- 作者：Francesca Mangialasche ; Alina Solomon ; Ingemar K氓reholt ; Babak Hooshm ; Roberta Cecchetti ; Laura Fratiglioni ; Hilkka Soininen ; Tiina Laatikainen ; Patrizia Mecocci ; Miia Kivipelto
- 关键词：AD ; Alzheimer's disease ; APOE ; Apolipoprotein E ; BMI ; Body mass index ; CAIDE ; Cardiovascular Risk Factors ; Aging ; and Dementia study ; CDR ; Clinical Dementia Rating Scale ; CERAD ; Consortium to Establish a Registry for Alzheimer's Disease ; CI ; Confidence interval ; CNS ; Central nervous system ; CV ; Coefficient of variation ; DSM-IV ; Diagnostic and Statistical Manual of Mental Disorders ; Fourth Edition ; HDL ; High-density lipoprotein ; HPLC ; High Performance Liquid Chromatography ; LDL ; Low-density lipop
- 刊名：Experimental Gerontology
- 出版年：December, 2013
- 年：2013
- 卷：48
- 期：12
- 页码：1428-1435
- 全文大小：321 K
Background
Vitamin E includes eight natural antioxidant compounds (four tocopherols and four tocotrienols), but 伪-tocopherol has been the main focus of investigation in studies of cognitive impairment and Alzheimer's disease.Objective
To investigate the association between serum levels of tocopherols and tocotrienols, markers of vitamin E oxidative/nitrosative damage (伪-tocopherylquinone, 5-nitro-纬-tocopherol) and incidence of cognitive impairment in a population-based study.
Design
A sample of 140 non-cognitively impaired elderly subjects derived from the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study was followed-up for 8 years to detect cognitive impairment, defined as development of mild cognitive impairment (MCI) or Alzheimer's dementia. The association between baseline serum vitamin E and cognitive impairment was analyzed with multiple logistic regression after adjusting for several confounders.
Results
The risk of cognitive impairment was lower in subjects in the middle tertile of the 纬-tocopherol/cholesterol ratio than in those in the lowest tertile: the multiadjusted odds ratio (OR) with 95% confidence interval (CI) was 0.27 (0.10-0.78). Higher incidence of cognitive impairment was found in the middle [OR (95% CI): 3.41 (1.29-9.06)] and highest [OR (95% CI): 2.89 (1.05-7.97)] tertiles of the 5-NO2-纬-tocopherol/纬-tocopherol ratio. Analyses of absolute serum levels of vitamin E showed lower risk of cognitive impairment in subjects with higher levels of 纬-tocopherol, 尾-tocotrienol, and total tocotrienols.
Conclusions
Elevated levels of tocopherol and tocotrienol forms are associated with reduced risk of cognitive impairment in older adults. The association is modulated by concurrent cholesterol concentration. Various vitamin E forms might play a role in cognitive impairment, and their evaluation can provide a more accurate measure of vitamin E status in humans.