Aggressive characteristics of myeloblasts expressing CD7 in myelodysplastic syndromes

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• 作者：Chikako Satoh ; Hideto Tamura ; Taishi Yamashita ; Takashi Tsuji ; Kazuo Dan ; Kiyoyuki Ogata
• 关键词：Myelodysplastic syndromes ; CD7 ; CD34 ; Myeloblasts ; Apoptosis ; IL-8 ; CCL2
• 刊名：Leukemia Research
• 出版年：2009
• 出版时间：February 2009
• 年：2009
• 卷：33
• 期：2
• 页码：326-331
• 全文大小：557 K

文摘

Clinical data suggest that CD7+ myeloblasts are linked with poor prognosis in myeloid malignancies including myelodysplastic syndromes (MDS). To explore the biology behind this, we compared cell characteristics between CD34+CD7+ and CD34+CD7− myeloblasts from an MDS cell line and fresh samples from MDS patients. Compared with CD34+CD7− myeloblasts, CD34+CD7+ myeloblasts showed greater proliferative capacity, more active cell cycling, and less apoptosis. In analyses of a cell line, CD34+CD7+ myeloblasts produced CD34+CD7− myeloblasts and showed lower expressions of interleukin-8 and chemokine (C–C motif) ligand 2 genes, suggesting immaturity of these cells. These findings might underlie the clinical aggressiveness in CD7+ MDS.