FGFR1-5-HT1A Heteroreceptor Complexes: Implications for Understanding and Treating Major Depression

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• 作者：Dasiel O. Borroto-Escuela¹ ; Alexander O. Tarakanov² ; Kjell Fuxe¹ ; ^{Kjell.Fuxe@ki.se" class="auth_mail" title="E-mail the corresponding author}
• 关键词：fibroblast growth factor receptor 1 ; 5-HT1A receptor ; heteroreceptor complexes ; allosteric receptor&ndash ; receptor interactions ; depression ; neural plasticity
• 刊名：Trends in Neurosciences
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：39
• 期：1
• 页码：5-15
• 全文大小：2465 K

文摘

The serotonin and neurotrophic factor hypotheses of depression are well known. The discovery of brain fibroblast growth factor receptor 1 (FGFR1)–5 hydroxytryptamine receptor 1A (5-HT1A) heteroreceptor complexes, and their enhancement of neuroplasticity, offers an integration of these hypotheses at the molecular level. They were first described in the hippocampus and later in midbrain 5-HT neurons, where these heterocomplexes are enriched in 5-HT1A autoreceptors. Combined FGF2 and 5-HT1A agonist treatment increased the formation of these heterocomplexes and the facilitatory allosteric receptor–receptor interactions within them led to the enhancement of FGFR1 signaling and was associated with the development of antidepressant effects. We discuss these findings with regard to a theory of motifs critically involved in these interactions and suggest that these complexes represent novel targets for antidepressants.