Applicability and discriminative value of a semiautomatic three-dimensional spherical volume for the assessment of the apparent diffusion coefficient in suspicious breast lesions—feasibility study

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• 作者：Jan Hering^f ; Frederik Bernd Laun^b ; Wolfgang Lederer^c ; Heidi Daniel^d ; Tristan Anselm Kuder^b ; Anne Stieber^e ; Stefan Delorme^a ; Klaus H. Maier-Hein^f ; Heinz-Peter Schlemmer^a ; Sebastian Bickelhaupt^a ; ^{S.Bickelhaupt@dkfz.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Diffusion-weighted imaging (DWI) ; Breast MRI ; Automatic lesion analysis ; Spherical metrics ; Breast cancer
• 刊名：Clinical Imaging
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：40
• 期：6
• 页码：1280-1285
• 全文大小：819 K

文摘

To evaluate the feasibility and accuracy of a semiautomatic, three-dimensional volume of interest (3D sphere) for measuring the apparent diffusion coefficient (ADC) in suspicious breast lesions compared to conventional single-slice two-dimensional regions of interest (2D ROIs).

Method

This institutional-review-board-approved study included 56 participants with Breast Imaging Reporting and Data System 4/5 lesion. All received diffusion-weighted imaging magnetic resonance imaging prior to biopsy (b=0–1500 s/mm²). ADC values were measured in the lesions with both methods. Reproducibility and accuracies were compared.

Results

Area under the curve was 0.93 [95% confidence interval (CI) 0.86–0.99] for the 3D sphere and 0.91 (95% CI 0.84–0.98) for the 2D ROIs without significantly differing reproducibility (P=.45).

Conclusion

A semiautomatic 3D sphere could reliably estimate ADC values in suspicious breast lesions without significant difference compared to conventional 2D ROIs.