Quality of life after different oncologic interventions in head and neck cancer patients

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• 作者：Thomas Mü ; cke ; Janett Koschinski ; Klaus-Dietrich Wolff ; Anastasios Kanatas ; David A. Mitchell ; Denys J. Loeffelbein ^{th.mucke@gmx.de" class="auth_mail" title="E-mail the corresponding author muecke@mkg.med.tum.de" class="auth_mail" title="E-mail the corresponding author} ; Herbert Deppe ; Andrea Rau
• 关键词：Quality of life ; Oral cancer ; Osteoradionecrosis ; Radiation therapy
• 刊名：Journal of Cranio-Maxillofacial Surgery
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：43
• 期：9
• 页码：1895-1898
• 全文大小：211 K

文摘

Patient reported outcomes following head and neck cancer are of great importance, given the functional, psychological, and social impacts of the disease and its treatment. In addition, not only is the number of publications on health-related quality of life (HRQOL) increasing in a variety of specialties, but there is also a growing awareness of the potential role of HRQOL in practice. Therefore, we aimed to investigate the HRQOL of head and neck cancer patients following different oncologic interventions, using an internationally established test. In this cross-sectional study, we included three different groups of 32 patients each. Participants had histologically confirmed invasive oral squamous cell carcinoma (OSCC) in the anterior floor of the mouth. Group allocation was based on treatment modality, as follows: only surgery (group 1), operation and adjuvant radiotherapy (XRT) (group 2), and the additional presence of osteoradionecrosis (ORN) (group 3). All patients were questioned about their HRQOL, using the standardized University of Washington Quality of Life Questionnaire (UW-QOL). Surveys for groups 1 and 2 were conducted at least 24 months after the end of tumor-related treatment, in cases of ORN (group 3) 12 months after completion of disease-related treatment. A total of 96 patients were included into this study. The mean age was 62.79 ± 8.93 years. The patients in groups 1 and 2 revealed a reduced quality of life, of a greater magnitude after radiation therapy. Patients felt that radiotherapy was much worse than surgery; however, half of the patients stated that they would repeat radiation therapy if necessary. The subjective evaluation of the HRQOL after surgery and radiotherapy was a valuable instrument for assessing the rehabilitation of patients in the context of their function and quality of life. Radiation therapy can be considered a trigger of functional limitations and emotional distress that contributes to decreased HRQOL in patients with head and neck cancer.