Nosocomial spread of Klebsiella pneumoniae isolates producing bla_GES-4 carbapenemase at a Japanese hospital

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• 作者：Katsutoshi Yamasaki^a ; ^b ; ^{ktt-yamazaki@wakayamah.johas.go.jp} ; Masaru Komatsu^b ; Tamotsu Ono^c ; Hisaaki Nishio^d ; Noriyuki Sueyoshi^e ; Kaneyuki Kida^f ; Kaori Satoh^g ; Hirofumi Toda^g ; Isao Nishi^h ; Masahiro Akagiⁱ ; Tetsu Mizutaniⁱ ; Isako Nakai^j ; Tomomi Kofuku^j ; Tamaki Orita^k ; Takuya Zikimoto^l ; Tatsuya Nakamura^l ; Yasunao Wada^m
• 关键词：Nosocomial spread ; Carbapenemases ; GES-4
• 刊名：Journal of Infection and Chemotherapy
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：23
• 期：1
• 页码：40-44
• 全文大小：488 K
• 卷排序：23

文摘

Six Klebsiella pneumoniae clinical isolates resistant to various cephalosporins and cephamycins were identified in a Japanese general hospital, a tertiary care hospital, between November 2009 and April 2010. All K. pneumoniae isolates carried blaGES-4 and blaSHV-1, while 2 K. pneumoniae isolates also harbored blaCTX-M-15. The pulsed-field gel electrophoresis patterns revealed that these 6 K. pneumoniae isolates were almost identical, suggesting their clonal relatedness. Plasmid profiles and conjugation assays revealed that these blaGES-4 genes were located on similar conjugative plasmids. These data indicate that nosocomial spread caused by K. pneumoniae isolates producing blaGES-4 carbapenemase occurred at a Japanese general hospital. K. pneumoniae isolate harboring blaGES-4 is rarely reported in Japan, and, to the best of our knowledge, this is the second report of K. pneumoniae isolates harboring blaGES-4 that occurred nosocomial spread in Japan.