Claudin-31 contributes to corticosteroid-induced alterations in the barrier properties of the gill epithelium
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- 作者：Dennis Kolosov ; Andrew Donini ; Scott P. Kelly ; spk@yorku.ca
- 关键词：Tight junction ; Paracellular permeability ; Cortisol ; Fish ; Osmoregulation ; Knockdown
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2017
- 出版时间：5 January 2017
- 年：2017
- 卷：439
- 期：Complete
- 页码：457-466
- 全文大小：1292 K
- 卷排序：439
文摘
Knockdown of claudin-31 (cldn-31 KD) compromises gill epithelium integrity. Cldn-31 is a cortisol-responsive barrier protein in the gill epithelium. cldn-31 KD limits cortisol-induced gill epithelium tightening. Select cldn isoforms compensate for cldn-31 KD in the presence of cortisol. cldn-31 KD abolishes a cortisol-stimulated increase in gill Cldn-8d.