Differential diagnosis of membranous nephropathy with autoantibodies to phospholipase A2 receptor 1

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• 作者：Wolfgang Schlumberger ; Nora Hornig ; Sascha Lange ; Christian Probst ; Lars Komorowski ; Kai Fechner ; Cornelia D盲hnrich ; Winfried St枚cker
• 关键词：Membranous nephropathy ; Nephrotic syndrome ; Phospholipase A2 receptor 1 ; Autoantibodies ; Indirect immunofluorescence ; ELISA
• 刊名：Autoimmunity Reviews
• 出版年：February, 2014
• 年：2014
• 卷：13
• 期：2
• 页码：108-113
• 全文大小：552 K

文摘

Membranous nephropathy (MN) accounts for most cases of the nephrotic syndrome in adults. Recently, studies on the underlying pathomechanisms led to the identification of the podocyte M-type receptor for secretory phospholipase A2 (PLA₂R1) as a target antigen of circulating autoantibodies.

Autoantibodies to PLA₂R1 may not only play a role in the development of primary MN, but also serve as a marker for diagnosis, disease activity and therapy monitoring. Antibody detection is crucial to discriminate between patients with primary MN and those with a secondary form of the disease, as both forms require different diagnostic approaches and treatment strategies. Standardized test systems based on recombinant PLA₂R1 allow for the sensitive and specific analysis of anti-PLA₂R1 autoantibodies. Further research into pathogenic mechanisms and other disease markers can pave the way for improved patient care.